Premier, touted as a virtually smokeless cigarette that dramatically reduced the cancer-causing compounds inhaled by smokers, was made of. How Do Electronic Smokeless Cigarettes Work? There is sufficient evidence that the use of smokeless tobacco causes cancer in humans. Smokeless tobacco products come in different forms, but they can still cause cancer and other health problems. A fact sheet about the health risks associated with the use of smokeless tobacco. Smokeless tobacco contains carcinogens, which contribute to cancers.